Transcriptional signature of tolerogenic dendritic cells (tolDCs)

Genes reported as activated (up-regulated) or repressed (down-regulated) in tolerogenic dendritic cells by Robertson et al. (2021). Used to evaluate whether the tolDCs of the study acquire the expected tolerogenic signature (Figure 6 of the article; l6_DEGs_tolDcs_es).

Usage

tolDC_genes

Format

A data frame with 86 rows and 4 columns:

gene: Gene symbol.
tolDC_signature: Category reported by Robertson et al.: direction (Activated or Repressed) and set in which the gene was found: tolDCs generated with IL-10 (IL10), with IL-10 plus dexamethasone (IL10+DXM) or the consensus tolDC signature (tolDC_signature). Genes found in several sets list all of them, separated by commas.
biotype: Gene biotype (PCG or lncRNA).
link: Link to the source publication.

Source

Robertson H, et al. (2021). Transcriptomic analysis identifies a tolerogenic dendritic cell signature. Front Immunol 12:733231. doi:10.3389/fimmu.2021.733231

Details

The script that generates it is data-raw/lesson6_annotations.R.

Examples

table(tolDC_genes$tolDC_signature)
#> 
#>                                                    Activated - IL10 
#>                                                                   9 
#>                                                Activated - IL10+DXM 
#>                                                                   8 
#>                              Activated - IL10+DXM, Activated - IL10 
#>                                                                   1 
#>                   Activated - IL10+DXM, Activated - tolDC_signature 
#>                                                                   1 
#>                                         Activated - tolDC_signature 
#>                                                                  23 
#>                                                    Repressed - IL10 
#>                                                                   7 
#>                                                Repressed - IL10+DXM 
#>                                                                   8 
#>                                         Repressed - tolDC_signature 
#>                                                                  25 
#>                   Repressed - tolDC_signature, Repressed - IL10+DXM 
#>                                                                   3 
#> Repressed - tolDC_signature, Repressed - IL10+DXM, Repressed - IL10 
#>                                                                   1